Official Title: Disulfiram for Cocaine Abuse. Study Start Date: April Actual Primary Completion Date: December Actual Study. Disulfiram, a well-established medication for the treatment of alcoholism, has helped people addicted to cocaine reduce abuse of the drug from. Cocaine is used as powder for intranasal or intravenous use, or smoked as crack. Dependence on cocaine can cause major public health.
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Lower your cholesterol Keeping your kidneys healthy Top 10 healthy heart tips. Participants were middle-aged, mostly African American males, with an average of 20 years of cocaine use. How to get NHS help for your pain Which painkiller? In laboratory studies, people experiencing a disulfiram-cocaine interaction demonstrated increased heart rate and blood pressure and reported anxiety, paranoia, and restlessness. Sex differences in treatment response seemed likely," says Ms. The 32 women and 89 men met the criteria for cocaine dependence specified in the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition DSM-IV and reported abusing cocaine 13 days on average during the month and 2. The present study was undertaken to help elucidate disulfiram's influence on the reinforcing effects of cocaine in non-treatment seeking cocaine-dependent volunteers. This is Archived content. This appears to be at odds with outpatient clinical trials showing disulfiram decreases cocaine use  — . Trending Topics.
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Behav Pharmacol 87— Organizations we support:. Trial Registration Clinicaltrials. Oxford University Press is a department of the University of Oxford. Nevertheless, it is clear that disulfiram can enhance cocaine's cardiovascular effects under certain experimental conditions. Life Sci 3: — In one study, the investigators treated alcohol- and cocaine-addicted patients with disulfiram and various behavioral therapies; in the second, they tested disulfiram in opioid- and cocaine-addicted patients under treatment with methadone. Dbh knockout mice are also more sensitive to the effects of cocaine than their wild-type counterparts . Assessing cocaine use, single studies were in favour of disulfiram on number of weeks of abstinence click
one out of four comparisons when compared with placebo and on maximum weeks of consecutive abstinence and number of people achieving three or more weeks of consecutive abstinence in one study comparing disulfiram to no pharmacological treatment. Use of other centrally acting medications other than disulfiram was not allowed.