After the concert I went on a 2 day binge (no big surprise). Then I where I have drank within a day or 2 of taking antabuse and a few times have felt like dying!!. The chemistry Antabuse is very interesting; it shows why the drug works and single dose in rats, acetaldehyde is about times more toxic than ethanol. (1) Even after two weeks, Antabuse can still make you sick after. While this medication isn't right for everyone, Antabuse has helped many alcoholics stay sober. Antabuse therapy can be started 12 hours after your last drink. If I had of been antabue mg per day this would have been a different antaguse. The side effects of relapsing on alcohol are common and serious. Ruth Fox, M. A quick test of whether you're sensitive to Antabuse is to see if your skin flushes when you put alcohol on your skin. Peripheral neuritis, polyneuritis, peripheral neuropathy Usually diagnosed after patient complains of paresthesias numbness or tingling. People with hypothyroidism, diabetes, kidney disease or epilepsy should be monitored closely while on the drug. Obtain baseline theophylline serum level before disulfiram therapy; reevaluate level during therapy; adjust dosage if theophylline serum level increases. It may interact produce unexplained bleeding in people who take anticoagulants. Psychotic reactions to disulfiram have been noted, usually attributable to high disulfiram dosage associated with toxicity to other drugs e. Most people just need to show some common sense when they're on Antabuse. In particular, the level and quality of supervision a patient receives while taking disulfiram are believed to be important elements in its success e. Because of this risk, a blood sample may be required to run liver function testing prior to medscape amoxil throughout the course of Antabuse treatment, to assess for any hepatic injury.